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Table 3 Methodology comparison for BRAF

From: A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

 

# Clusters/Hotspots

Method/ Protein-structure

BRAF - 3Q96

ALK-2XBA

SpacePAC

3

2

NMC

22

11

iPAC

45

11

GraphPAC-Cheapest

36

7

GraphPAC-Nearest

45

8

GraphPAC-Farthest

47

6

  1. The number of clusters found under each method. As SpacePAC does not need to consider every pairwise combination of mutations, the method provides a much smaller number of potential hotspots while still covering the majority of mutations.
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BMC Bioinformatics

ISSN: 1471-2105

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