Figure 6
From: On the potential of models for location and scale for genome-wide DNA methylation data
EWAS results. Results for BMI (A and B) and age (C and D) effects on methylation level (μ) and variability (σ) are shown, respectively. Bold number in the right top corner: Number of CpG sites with genome-wide significant association (p<1.3·10-7) according to asymptotic test results. Numbers in the box represent percentages of associations that were significant according to resampling-based inference (red circle) and/or that were validated in the independent F3 study (at p<0.05, blue circle), or neither of them (bottom right). Numbers in brackets indicate the respective percentage of positive associations. p-values are from Fisher’s exact tests for enrichment of validated associations among the resampling-significant associations.