Table 1 Competing models for methylation data analysis

Fixed scale models

raw (ra)

y

Gaussian

μ only

logit2 (lo)

$\underset{2}{log}\left(\frac{y}{1-y}\right)$

Gaussian

μ only

arcsine (ar)

$\stackrel{-1}{sin}\left(\sqrt{y}\right)$

Gaussian

μ only

beta (be)

y

beta

μ only

Variable scale models

raw+ (ra+)

y

Gaussian

μ and σ

logit2+ (lo+)

$\underset{2}{log}\left(\frac{y}{1-y}\right)$

Gaussian

μ and σ

arcsine+ (ar+)

$\stackrel{-1}{sin}\left(\sqrt{y}\right)$

Gaussian

μ and σ

beta+ (be+)

y

beta

μ and σ