Figure 1

dSIM detects correct regions. (A): 1 of 50 runs for simulation study 1 with no difference in association patterns. (B): 1 of 50 runs for simulation study 2 with different levels of association effects between the groups. (C): 1 of 50 runs for simulation study 3 with association patterns for one group while no associations between copy number and gene expression for the other group. Significant p-values, selected by Meinshausen’s procedure at significance level 0.01 (horizontal black dotted line), are the ones close to 0. The regions with differential associations in each of the three cases, are marked by gray dotted bars. (D): This figure summarizes the accuracy, sensitivity and specificity for the 50 simulation runs.