Figure 2

dSIM corrects for baseline effect. (A): 1 of 50 runs for case 1.1 with no differential association and similar distribution of copy number aberrations between the groups of samples. (B): 1 of 50 runs for case 1.2 with no differential association and different distribution of copy number aberrations between the groups of samples. (C): Accuracy, sensitivity and specificity for 50 runs, for the two simulation studies under case 1. (D): 1 of 50 runs for case 2.1 with differential association and similar distribution of copy number aberrations between the groups of samples. (E): 1 of 50 runs for case 2.2 with differential association and different distribution of copy number aberrations between the groups of samples. (F): Accuracy, sensitivity and specificity for 50 runs, for the two simulation studies under case 2. Significant p-values, selected by Meinshausen’s procedure at significance level 0.01 (horizontal black dotted line), are the ones close to 0. The regions with differential associations in each of the four figures, are marked by gray dotted bars.