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Figure 4 | BMC Bioinformatics

Figure 4

From: Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

Figure 4

NPA of the TNF-IL1 α -TLR-NF κ B network in patients with Ulcerative colitis for the comparisons: IFX non-responders vs. control cases, IFX responders vs. control cases and IFX responders vs. IFX non-responders. The right-hand side of panel b) shows the TopoNPA scores for the samples collected after IFX treatment (GSE16879), while the other bar plots shows the TopoNPA scores before IFX treatment (GSE 12251 & GSE14580 (panel a)), GSE16879 (panel b) left-hand side). The significance at the 0.05 level of the “O” and “K” statistics are indicated by ‘*o’ and ‘k*’, respectively, while the significance with respect to the experimental variation is indicated by a red star.

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BMC Bioinformatics

ISSN: 1471-2105

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