Differential network backbone values of TNF-IL1 α -TLR-NF κ B network for the comparison IFX responders vs. IFX non-responders from the two cohorts GSE12251 & 14580, showing stronger network perturbation for the IFX non-responder group. Blue shading indicates a negative value while red shading a positive one. The leading nodes are circled with green. Grey edges represent an activation while black edges an inhibition. Almost four thousands genes are underlying this network (Table 3).