Table 6 NPA leading nodes of the xenobiotic network for the comparison current smoker vs. never smoker, all are positive

1

taof(AHR) (+)

taof(AHR) (+)

2

Reactive Oxygen Species (+)

Diesel exhaust particles (+)

3

Diesel exhaust particles (+)

Reactive Oxygen Species (+)

4

taof(NFE2L2) (+)

NFE2L2 (+)

5

NFE2L2 (+)

taof(NFE2L2) (+)

6

8-Methyl-IQX (+)

8-Methyl-IQX (+)

7

AHR (+)

Polycyclic

Aromatic Hydrocarbons (+)

8

oxof(CYP2E1) (+)

catof(CYP1B1) (+)

9

Polycyclic

CYP1A1 (+)

Aromatic Hydrocarbons (+)

10

catof(CYP1B1) (+)

catof(CYP1A2) (+)

11

catof(CYP1A2) (+)

catof(CYP1A1) (+)

12

CYP1A1 (+)

Particulate Matter (+)

13

catof(CYP1A1) (+)

Soot (+)

14

Soot (+)

AHR (+)

15

oxof(CYP2E1) (+)