Skip to main content

Table 6 NPA leading nodes of the xenobiotic network for the comparison current smoker vs. never smoker, all are positive

From: Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

Rank GSE7895 GSE19667
1 taof(AHR) (+) taof(AHR) (+)
2 Reactive Oxygen Species (+) Diesel exhaust particles (+)
3 Diesel exhaust particles (+) Reactive Oxygen Species (+)
4 taof(NFE2L2) (+) NFE2L2 (+)
5 NFE2L2 (+) taof(NFE2L2) (+)
6 8-Methyl-IQX (+) 8-Methyl-IQX (+)
7 AHR (+) Polycyclic
   Aromatic Hydrocarbons (+)
8 oxof(CYP2E1) (+) catof(CYP1B1) (+)
9 Polycyclic CYP1A1 (+)
  Aromatic Hydrocarbons (+)  
10 catof(CYP1B1) (+) catof(CYP1A2) (+)
11 catof(CYP1A2) (+) catof(CYP1A1) (+)
12 CYP1A1 (+) Particulate Matter (+)
13 catof(CYP1A1) (+) Soot (+)
14 Soot (+) AHR (+)
15   oxof(CYP2E1) (+)
  1. The nodes also extracted by Nearest Shrunken Centroids are shown in bold.