Figure 5

Rules for optimal development of the crypt. Simulation results of the rules for optimal development of the crypt (see main text). The rules are executed with r₁ = 1.07, r₂ = 1, |SC|_Time = 0 = 1, |Diff|_Time = 0 = 0, |SC| _Target  = 10, |Diff| _Target  = 50 (values are taken from [27]). Shown are execution results for two time windows starting with one SC. (A) Schematic representation of the eSTG rules. (B) Population size for simulation time of 10 days. The beginning of the process is shown where the switch between p₁ = 1 and p₁ = 0 occurs at around time t = 3.6. (C) The corresponding lineage representation of the specific execution. (D) Population size for simulation time of 50 days. Shown is the homeostatic phase that occurs after |Diff|_Time = t reaches |Diff| _Target at around time t = 6. (E) The corresponding lineage representation of the specific execution. It is interesting to observe the 10 clones that are maintained by the 10 SCs.