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Figure 4 | BMC Bioinformatics

Figure 4

From: Hamiltonian Monte Carlo methods for efficient parameter estimation in steady state dynamical systems

Figure 4

Relative speed for the Simplified Manifold Metropolis-Adjusted Langevin Algorithm (SMMALA) using the same modifications as in the RMHMC code. We calculate the sensitivities using systems of linear equations, we use the sensitivities to obtain the metric and the starting point for the Newton Raphson method which is used to calculate steady states. We tested the relative speed of both the modified and unmodified SMMALA on all three example models with uninformative priors. In all cases, the modified version of SMMALA was faster than the reference implementation.

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