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Table 1 The three classes of interactions and corresponding interaction types

From: Incorporating the type and direction information in predicting novel regulatory interactions between HIV-1 and human proteins using a biclustering approach

Interaction classes Interaction types
Class-1 (Direction of regulation is from viral to host proteins) acetylates, activates, cleaves, decreases phosphorylation of, deglycosylates, degrades,depolymerizes, disrupts, downregulates, enhances, enhances polymerization of,inactivates, incorporates, induces accumulation of, induces acetylation of, inducescleavage of, induces complex with, induces phosphorylation of, induces rearrangement of, induces release of, inhibits, inhibits acetylation of, modulates, phosphorylates, polarizes, recruits, upregulates, relocalizes, sensitizes, stabilizes, stimulates, upregulates, regulates
Class-2 (Direction of regulation is from host to viral proteins) acetylated by, activated by, cleavage induced by, cleaved by, degraded by,downregulated by, enhanced by, exported by, glycosylated by, imported by, inhibited by, isomerized by, mediated by, methylated by, modified by, modulated by, myristoylated by, palmitoylated by, phosphorylated by, processed by, recruited by, regulated by,relocalized by, stimulated by, ubiquitinated by, upregulated by
Class-3 (Bidirectional) co-localizes with, binds, competes with, complexes with, cooperates with, fractionateswith, associates with, interacts with, requires, synergizes with