Biclique | HIV protein | Human protein | GO term (bp) | GO term (cc) | GO term (mf) | KEGG pathway |
---|---|---|---|---|---|---|
1 | env_gp120 env_gp160 env_gp41 | MAN1B1 MGAT2 MAN2C1 MAN2A1 MAN2A2 MANBA GBA3 MAN2B2 GAA MAN2B1 MAN1A1 MAN1A2 MAN1C1 GCS1 GANAB GANC GBA2 | Mannose metabolic process (GO:0006013) (4.5E-11) | Golgi apparatus part (GO:0044431) (6.9E-6) | Mannosidase activity (GO:0015923) (8.7E-25) | N-Glycan biosynthesis (1.0E-11) |
2 | Rev capsid matrixnucleocapsid p1 p6 | UBB UBC UBD | Long-term strengthening of neuromuscular junction (GO:0042062) (7.4E-4) | Cytosolic small ribosomal subunit (GO:0022627) (3.1E-3) | Structural constituent of ribosome (GO:0003735) (1.3E-2) | Not found |
3 | Rev Tat matrix p6 | MAPK1 MAPK3 UBB UBC UBD | Cell cycle (GO:0007049)(7.2E-4) | Nucleoplasm (3.3E-4) | MAP kinase activity (GO:0004707) (3.2E-3) | Dorso-ventral axisformation (1.5E-2) |
4 | RT Vif env_gp120 | IFNA1 IFNA16 IFNA2 IFNA7 | Response to virus (GO:0009615) (5.1E-7) | Extracellular space (GO:0005615) (1.5E-4) | Interferon-alpha/beta receptor binding (GO:0005132) (2.3E-10) | Regulation of autophagy (3.0E-7) |
5 | Rev Vpu matrix retropepsin | CSNK2A1 CSNK2A2 CSNK2B | Wnt receptor signaling pathway (GO:0016055) (GO:0016055) (9.6E-5) | Not found | Protein serine/threoninekinase activity (Adherensjunction (2.3E-4) | Â |
6 | Rev Tat Vif matrix p6 | MAPK1 MAPK3 | Ras protein signaltransduction (GO:0007265) (7.8E-3) | Nucleolus (GO:0005730)(5.5E-2) | MAP kinase activity (GO:0004707) (1.1E-3) | Dorso-ventral axis formation (4.9E-3) |
7 | RT Rev Vpu matrix retropepsin | CSNK2A1 CSNK2B | Wnt receptor signaling pathway (GO:0016055) (9.8E-3) | Not found | Protein serine/threonine kinase activity (GO:0004674) (3.3E-2) | Adherens junction (1.5E-2) |
8 | RT Rev matrix | CSNK2A1 CSNK2B PRKCA | Wnt receptor signaling pathway (GO:0016055) (2.0E-2) | Not found | Protein serine/threonine kinase activity (GO:0004674) (1.1E-3) | Tight junction junction (6.9E-4) |
9 | Tat integrase matrix | KPNB1 RANBP5 TNPO1 | Protein import into nucleus, docking (GO:0000059) (1.3E-3) | Nuclear pore (GO:0005643) (6.2E-3) | Nuclear localization sequence binding (GO:0008139) (5.4E-4) | Not found |
10 | Rev Tat matrix | MAPK1 MAPK3 PRKCA UBB UBC UBD | Regulation ofsynaptogenesis(GO:0051963) (1.7E-5) | Cytosol (GO:0005829)(1.2E-4) | MAP kinase activity (GO:0004707) (4.3E-3) | Aldosterone-regulated sodium reabsorption (6.3E-5) |
11 | Nef env_gp120 env_gp160 | CD4 ITGAL ICAM1 HLA-DRB1 PRKCQ LCK | T cell activation (GO:0006468) (7.8E-6) | Plasma membrane part (GO:0044459) (1.5E-4) | Glycoprotein binding (GO:0001948) (1.4E-2) | Cell adhesion molecules (CAMs) (1.6E-4) |
12 | Tat capsid env_gp120 | IFNG CD3D CD3E CD3G | T cell activation (GO:0042110) (2.6E-4) | Alpha-beta T cell recep- tor complex (GO:0042105) (2.2E-7) | T cell receptor binding (GO:0042608) (6.9E-4) | T cell receptor signaling pathway (9.3E-6) |
13 | Nef env_gp120 env_gp41 | CXCR4 CD4 | Initiation of viral infection (GO:0019059) (1.6E-3) | Not found | Coreceptor activity (GO:0015026) (1.5E-3) | Not found |
14 | Nef Tat env_gp120 | TP53 ICAM1 | T cell activation during immune response (GO:0002286) (9.6E-4) | Not found | Not found | Not found |
15 | Nef Tat Vpr | CDK9 TP53 | Transcription,DNA-dependent(GO:0006351) (2.2E-2) | Nucleoplasm part (GO:0044451) (4.3E-2) | Not found | Not found |
16 | Nef RT Tat | PRKCA TP53 | Induction of apoptosis by intracellular signals (GO:0008629) (4.0E-3) | Nsoluble fraction (GO:0005626) (6.6E-2) | Not found | Non-small cell lung cancer (1.1E-2) |
17 | Tat env_gp120 env_gp160 | CD28 ICAM1 | Regulation of immune effector process (GO:0002697) (7.5E-3) | External side of plasma membrane (GO:0009897) (1.3E-2) | Â | Viral myocarditis (1.4E2) |
18 | Tat Vpr env_gp120 | TP53 NFKB1 | Regulation of specific transcription from RNA polymerase II promote(GO:0006357)(6.9E-3) | Nucleoplasm (GO:0005654) (3.3E-4) | Promoter binding (GO:0010843) (4.4E-3) | Pancreatic cancer (1.4E-2) |
19 | Tat env_gp120 env_gp41 | CCL5 IFNG | Leukocyte chemotaxis (GO:0030595) (2.7E-3) | Extracellular space (GO:0005615) (5.4E-2) | Cytokine activity (GO:0005125) (1.5E-2) | Cytokine-cytokinereceptor interaction (5.2E-2) |