Figure 1
From: A phenome-guided drug repositioning through a latent variable model
Overview of the study. A) Integrating side-effects and indications to complete phenome; B) Determining the number of topics by using information loss; C) Hiding known indications one by one to see the recovery potential for decision criteria; D) Developing the decision criteria considering recovered indications with significance; E-F) LDA is applied to the drug-phenome matrix. Observing the decision criteria, real indications were recovered for drugs without indication information and new indications suggested for remaining drugs.