Figure 3
The results of CoMDP on the GBM1 dataset with k =4 and k =5, and the related p53 and RB pathways. (A) The co-occurrence between the two gene sets {CDKN2A, M G1} and {MTAP, CYP27B1} identified by CoMDP with k=4 in the GBM1 dataset. (B) The TP53 and RB tumor suppressor pathways. ARF and INK4A are two alternatively spliced transcripts of CDKN2A. This figure was adapted/extracted according to [31, 32]. (C) The alterative gene regulatory pathway ((a) or (b)) involving CDKN2A, CDK4 and TP53.