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Table 3 Co-occurring gene sets identified by applying CoMDP to GBM2 with somatic mutations and CNAs

From: Discovery of co-occurring driver pathways in cancer

k Gene set 1 Gene set 2 p 1 p 2 n 1 n 2 r 1,2 p 1,2
4 CDKN2A, M G 3 CDKN2B, CYP27B1 0.0045 0.0056 60 63 0.9219 <0.0001
  CDKN2A,        
5 CYP27B1, COL1A2 CDKN2B, M G 3 0.0072 0.0018 62 63 0.9531 <0.0001
  CDKN2A, CDKN2B,       
6 CYP27B1, COL1A2 M G3, ERBB2 0.0073 0.0003 62 65 0.9538 <0.0001
  CDKN2A, TP53, CDKN2B, RB1,       
7 M G 3 , TAF1 CYP27B1 0.0001 0.0001 77 70 0.8375 <0.0001
  CDKN2A, TP53, CDKN2B, RB1,       
8 M G 3 , TAF1 CYP27B1, PRNP 0.0002 <0.0001 77 71 0.8500 <0.0001
  CDKN2A, TP53, TAF1, CDKN2B, RB1,       
9 M G 3 , PIK3R1 CYP27B1, SYNE1 0.0002 <0.0001 79 72 0.8642 <0.0001
  CDKN2A, TP53, TAF1, CDKN2B, RB1, SYNE1,       
10 M G 3 , PIK3R1 CYP27B1, M G 4 0.0001 <0.0001 79 73 0.8765 <0.0001
  1. MG3 is a metagene including three genes: CDK4, MARCH9, TSPAN31. MG4 is a metagene including 168 genes.