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Table 2 Functional analysis of novel nsSNV containing genes

From: Non-synonymous variations in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data

Analysis Functional object Observed Expected +/- P value
PANTHER pathways Integrin signaling pathway 147 99.09 + 6.43E-04
Cadherin signaling pathway 109 74.91 + 2.15E-02
Endothelin signaling pathway 62 38.88 + 6.55E-02
Gonadotropin releasing hormone receptor pathway 174 133.70 + 7.71E-02
Nicotinic acetylcholine receptor signaling pathway 75 49.78 + 8.78E-02
PANTHER protein classification Cell adhesion molecule 443 316.70 + 9.28E-10
G-protein modulator 346 238.47 + 3.82E-09
enzyme modulator 906 730.11 + 5.69E-09
kinase 431 312.91 + 1.28E-08
cytoskeletal protein 585 452.77 + 1.02E-07
GO biological process Cell communication 2333 2002.60 + 3.16E-14
Cell adhesion 820 616.80 + 6.15E-14
Signal transduction 2204 1905.41 + 5.32E-12
Cellular component organization 773 595.00 + 4.72E-11
Protein modification process 804 630.55 + 5.80E-10
GO molecular function Hydrolase activity 1295 1053.92 + 1.81E-12
Transferase activity 962 759.03 + 1.12E-11
Protein binding 1715 1456.91 + 5.40E-11
Transmembrane transporter activity 609 460.35 + 9.79E-10
Enzyme regulator activity 732 576.51 + 1.05E-08
GO cellular component Cytoskeleton 585 452.77 + 2.03E-08
Intracellular 681 540.47 + 3.98E-08
Actin cytoskeleton 302 229.94 + 8.66E-05
MHC protein complex 18 40.30 - 2.37E-03
Extracellular matrix 327 264.55 + 3.33E-03