Table 2 Given a reference r and a gene-disease pair < g , d >, CRFref estimates and integrates three measures: degrees of conclusiveness , richness , and focus of r with respect to < g , d > 

$\left\{\begin{array}{c}\hfill 1\mathit{if}\mathit{length}\mathit{of}r>\mathit{AvgLe}{n}^{\left[a\right]}\hfill \\ \hfill \frac{L\mathrm{ength}\mathrm{of}r}{\mathrm{AvgLen}}\mathit{otherwise}\hfill \end{array}\right.$

$\left\{\begin{array}{c}\hfill 1\mathit{if}\mathit{TF}\left(g,r\right)>5^{\left[b\right]}\hfill \\ \hfill \frac{\mathit{TF}\left(g,r\right)}{5}\mathit{otherwise}\hfill \end{array}\right.$

$\left\{\begin{array}{c}\hfill 1\mathit{if}\mathit{TF}\left(d,r\right)>5\hfill \\ \hfill \frac{\mathrm{TF}\left(d,r\right)}{5}\mathit{otherwise}\hfill \end{array}\right.$

$\left\{\begin{array}{c}\hfill 1\mathit{if}g\mathrm{appears}\mathrm{in}\mathrm{the}\mathrm{title}\mathrm{of}r\hfill \\ \hfill 0\mathrm{otherwise}\hfill \end{array}\right.$

$\left\{\begin{array}{c}\hfill 1\mathrm{if}d\mathrm{appears}\mathrm{in}\mathrm{the}\mathrm{title}\mathrm{of}r\hfill \\ \hfill 0\mathrm{otherwise}\hfill \end{array}\right.$

$\frac{\mathit{LastPos}{\left(g,r\right)}^{\left[c\right]}}{\mathrm{length}\mathrm{of}r}$

$\frac{\mathit{LastPos}\left(d,r\right)}{\mathrm{length}\mathrm{of}r}$

$\begin{array}{c}\left\{\begin{array}{c}\hfill 1\mathit{if}\left|G^{\text{'}}\right|>5\hfill \\ \hfill \frac{\left|G^{\text{'}}\right|}{5}\mathit{otherwise}\hfill \end{array}\right.\\ G^{\text{'}}={\left\{g^{\text{'}}|g\text{'}\in G-\left\{g\right\}\mathit{and}\mathit{appears}\mathit{in}r\right\}}^{\left[d\right]}\end{array}$

$\begin{array}{c}\left\{\begin{array}{c}\hfill 1\mathit{if}\left|D^{\text{'}}\right|>5\hfill \\ \hfill \frac{\left|D^{\text{'}}\right|}{5}\mathit{otherwise}\hfill \end{array}\right.\\ D^{\text{'}}={\left\{d^{\text{'}}|d\text{'}\in D-\left\{d\right\}\mathit{and}\mathit{appears}\mathit{in}r\right\}}^{\left[e\right]}\end{array}$

$\left\{\begin{array}{c}\hfill 1\mathrm{if}\mathrm{there}\mathrm{is}\mathrm{a}\mathrm{gene}{g}^{\text{'}}\in G-\left\{g\right\}\mathrm{that}\mathrm{appears}\mathrm{in}\mathrm{the}\mathrm{title}\mathrm{of}r\hfill \\ \hfill 0\mathrm{otherwise}\hfill \end{array}\right.$

$\left\{\begin{array}{c}\hfill 1\mathrm{if}\mathrm{there}\mathrm{is}\mathrm{a}\mathrm{disease}{d}^{\text{'}}\in D-\left\{d\right\}\mathrm{that}\mathrm{appears}\mathrm{in}\mathrm{the}\mathrm{title}\mathrm{of}r\hfill \\ \hfill 0\mathrm{otherwise}\hfill \end{array}\right.$

$\frac{\mathit{Ma}{x}_{g^{\text{'}}\in G-\left\{g\right\}\mathrm{and}\mathrm{appears}\mathrm{in}r}\mathit{LastPos}\left(g^{\text{'}},r\right)}{\mathrm{length}\mathrm{of}r}$

$\frac{\mathit{Ma}{x}_{d^{\text{'}}\in D-\left\{d\right\}\mathrm{and}\mathrm{appears}\mathrm{in}r}\mathit{LastPos}\left(d^{\text{'}},r\right)}{\mathrm{length}\mathrm{of}r}$