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Table 3 Average (50 replicates) execution time (standard deviation) of simulating 5-Mb sequence with recombination hotspots (hh:mm:ss)*

From: Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences

Number of hotspots

N

ms

msHOT

MacsCS

Simcoal2*

Fastsimcoal

0

100

1:48 (0:03)

1:49 (0:03)

0:17 (0:02)

1:08:23 (4:22)

0:03 (4×10-3)

500

---

---

0:48 (0:03)

1:17:02 (4:41)

0:16 (0:02)

1,000

---

---

1:39 (0:07)

1:20:57 (7:23)

0:40 (0:02)

10,000

---

---

29:45 (1:22)

1:55:01 (8:21)

12:36 (0:14)

2

100

---

1:36:18 (8:41)

0:17 (0:03)

1:16:16 (4:30)

0:03 (4×10-3)

500

---

1:54:09 (6:20)

0:51 (0:08)

1:17:29 (6:23)

0:17 (0:03)

1,000

---

1:59:32 (7:30)

1:32 (0:10)

1:25:50 (7:31)

0:40 (0:03)

10,000

---

2:02:28 (10:52)

30:02 (3:04)

2:08:31 (7:24)

13:01 (0:10)

5

100

---

3:08:45 (13:11)

0:19 (0:3)

1:09:38 (7:10)

0:04 (0:01)

500

---

3:23:29 (16:08)

0:49 (0:07)

1:10:59 (10:03)

0:17 (0:02)

1,000

---

3:31:39 (17:14)

1:34 (0:12)

1:24:10 (9:37)

0:41 (0:05)

 

10,000

---

4:12:07 (20:06)

36:50 (5:47)

1:57:03 (14:20)

13:17 (0:12)

  1. * “N” denotes sample size (i.e., the number of DNA sequences) for each replicate. “---” denotes a segmentation fault (e.g., ms could not simulate sequence data with recombination hotspots).