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Table 3 Average (50 replicates) execution time (standard deviation) of simulating 5-Mb sequence with recombination hotspots (hh:mm:ss)*

From: Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences

Number of hotspots N ms msHOT MacsCS Simcoal2* Fastsimcoal
0 100 1:48 (0:03) 1:49 (0:03) 0:17 (0:02) 1:08:23 (4:22) 0:03 (4×10-3)
500 --- --- 0:48 (0:03) 1:17:02 (4:41) 0:16 (0:02)
1,000 --- --- 1:39 (0:07) 1:20:57 (7:23) 0:40 (0:02)
10,000 --- --- 29:45 (1:22) 1:55:01 (8:21) 12:36 (0:14)
2 100 --- 1:36:18 (8:41) 0:17 (0:03) 1:16:16 (4:30) 0:03 (4×10-3)
500 --- 1:54:09 (6:20) 0:51 (0:08) 1:17:29 (6:23) 0:17 (0:03)
1,000 --- 1:59:32 (7:30) 1:32 (0:10) 1:25:50 (7:31) 0:40 (0:03)
10,000 --- 2:02:28 (10:52) 30:02 (3:04) 2:08:31 (7:24) 13:01 (0:10)
5 100 --- 3:08:45 (13:11) 0:19 (0:3) 1:09:38 (7:10) 0:04 (0:01)
500 --- 3:23:29 (16:08) 0:49 (0:07) 1:10:59 (10:03) 0:17 (0:02)
1,000 --- 3:31:39 (17:14) 1:34 (0:12) 1:24:10 (9:37) 0:41 (0:05)
  10,000 --- 4:12:07 (20:06) 36:50 (5:47) 1:57:03 (14:20) 13:17 (0:12)
  1. * “N” denotes sample size (i.e., the number of DNA sequences) for each replicate. “---” denotes a segmentation fault (e.g., ms could not simulate sequence data with recombination hotspots).