Figure 5

Close functional relationships between genes with point mutations and copy number changes in the same somatic genome. The relations were first prioritized for their significant co-occurrence with point mutations in TP53, and then for enrichment in network connections with other point mutations. Red nodes indicate genes with point mutations detected in the OV tumor sample TCGA-13-0906-10; Yellow nodes indicate a pair of genes that both exhibited copy number losses in the same genome, both of which were highly ranked as drivers in this genomic context.