Figure 6

Collagen-associated network affected by somatic mutagenesis in GBM, as identified by the network analysis. The sub-network was retrieved from http://funcoup2.sbc.su.se by searching for direct links that connect genes with point mutations (red), copy number alterations (yellow), and LOX genes (grey). Each of the red and yellow nodes represents a gene with a driver role established via 1) network enrichment analysis against either known cancer pathways or sets of genes with point mutations in the same tumor, and 2) significant association (co-occurrence) with collagen mutations (or being collagens themselves). The network edges shown in the figure are independent of the latter analysis because the whole network was compiled using the FunCoup tool based on multiple sources of high-throughput, annotation, and literature data.