Figure 11From: Polyphony: superposition independent methods for ensemble-based drug discoveryCorrelated conformational change. The 25 most highly correlated pairs of residues separated in sequence by at least 30 amino acids. (a) backbone. The correlation coefficients range from 0.84 between Asn 59 at the end of the PSTAIRE helix and Phe 146 of the DFG motif, to 0.65 (b) side-chains. Leu 115 and Leu 189 in the core of CDK2 switch rotamers on protein binding.Back to article page