Figure 14
From: Polyphony: superposition independent methods for ensemble-based drug discovery
Plot of the group variance S (see Equation 5) for CGMC protein kinases. Groups were clusters of very closely related structures (1% Pearson distance cutoff). (a) CDK6, n = 12 in 9 groups (b) CDK2, 290 in 93 (c) ERK2, 27 in 18 (d) p38α, 186 in 75 (e) JNK3, 32 in 22 (f) consensus (average S). The colours indicate the glycine rich loop (pink), the hinge region (orange), the DFG motif (grey), the T-loop (yellow) and αEF-αF loop (cyan).