Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection

Table 3 Ten co-regulation motifs and their occurrence frequencies in the background network and the activated network

Motif ID	Network	Occurrence	Z-Score
M1	Background	1541	24.114
M1	Active	16	153.470
M2	Background	21317	8.412
M2	Active	209	2.356
M3	Background	45171	-3.933
M3	Active	109	-54.482
M4	Background	27987	3.685
M4	Active	153	1.053
M5	Background	187341	-1.152
M5	Active	1647	-20.769
M6	Background	2931	-1.091
M6	Active	-	-
M7	Background	20060	1.017
M7	Active	59	0.914
M8	Background	3226	-0.624
M8	Active	13	25.591
M9	Background	481293	-0.478
M9	Active	38	0.626
M10	Background	88102	-0.230
	Active	273	-24.802

Motifs are ordered according to their absolute Z-scores in the background regulatory network, which are calculated using FANMOD [50]. Motifs 'M1’, 'M2’, and 'M3’ are statistically significant in both the background and the activated regulatory networks (threshold of 2). 'M5’, 'M8’ and 'M10’ are not statistically significant in the background regulatory network, while they become significant in the activated regulatory network.