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Figure 7 | BMC Bioinformatics

Figure 7

From: Bison: bisulfite alignment on nodes of a cluster

Figure 7

Methylation percentage and coverage comparison using the RRBS dataset. The Pearson’s correlation coefficients of the per-CpG estimated methylation percentages produced by each aligner are generally high, A, upper triangle. The correspondence between GNUMAP-bs and BS-Seeker2 and the other aligners, however, is notably lower, possibly due to their lower alignment rate. The Pearson’s correlation coefficients of the per-CpG coverage, A, lower triangle, is also generally high. The number of CpGs with a given coverage decreases rapidly as a function of coverage regardless of aligner, B. Note that CpGs with 251 or greater methylation calls are binned together. This binning produces the large spike at 251x coverage, which is likely due to PCR duplication.

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