Figure 1

Overview of sources of DFLAT annotation. On the left-hand side, neonatologists suggest keywords and developmental processes for manual curation of the literature, which proceeds according to the methodology of the Gene Ontology Consortium. Eligible annotations are submitted to the Gene Ontology and included in subsequent data releases. Others, valuable for our purposes, become part of the “GONE” collection. The right-hand side of the image depicts our procedure for deriving annotation from mouse orthologs. Mouse genes of interest are identified by having GO annotations in the “Developmental Process” subtree. For those genes for which MGI has identified unique human orthologs, all mouse annotations with the required evidence codes are mapped to the corresponding human gene.