Figure 4

Comparison of average strengths of hotspots between SNP alleles that preserve and disrupt the PRDM9 motif of CCTCCCT. We collected hotspot-SNP pairs with significant LDsplit p-values where the SNPs are inside PRDM9 motif. For SNP alleles preserving the motif form of CCTCCCT, the allele-specific recombination profiles of the hotspots are averaged into the red profile in the figure. For the same list of hotspot-SNP pairs, the blue profile plots the average recombination hotspots estimated from haplotypes of SNP alleles that disrupt the CCTCCCT motif.