HMMvar and Provean score distributions and mean/error bars of TP53 mutations binned into 15 classes in terms of transactivity level. (a) HMMvar score distribution of the 15 classes (x-axis represents the 15 classes based on the median of transactivity levels). (b) Provean score distribution of the 15 classes. (c) Mean along with error bar of HMMvar scores in each class. (d) Mean along with error bar of Provean scores in each class.