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Table 1 Results of MSEA in a comparative study of normal and 12 h-fasted mice

From: Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis

 

ORA

Subramanian's approach

 

Positive correlation with PC1

Negative correlation with PC1

Positive correlation with PC1

 

p-value

q-value

p-value

q-value

NES

p-value

q-value

Glycolysis

1.0000

1.0000

0.0001*

0.0036**

-2.0048

0.0000*

0.0074**

Pentose phosphate pathway

1.0000

1.0000

0.0308*

0.2000

-1.6040

0.0283*

0.1781

TCA cycle

1.0000

1.0000

0.0040*

0.0519

-1.6208

0.0165*

0.2433

Glutamic acid and glutamine metabolism

1.0000

1.0000

0.4901

0.9801

-1.0936

0.3497

0.5193

Alanine, aspartic acid and asparagine metabolism

0.8254

1.0000

0.2878

0.8313

-1.1897

0.2625

0.4379

Lysine metabolism

0.8567

1.0000

0.8681

1.0000

-0.8172

0.7078

0.8274

Valine, leucine and isoleucine metabolism

1.0000

1.0000

0.7735

1.0000

-0.9392

0.5636

0.7311

Glycine, serine and threonine metabolism

0.7434

1.0000

0.0720

0.2445

-1.2557

0.1803

0.3704

Cysteine metabolism

0.6489

1.0000

0.0412*

0.2142

-1.3259

0.1611

0.3371

Methionine metabolism

0.6178

1.0000

0.8444

1.0000

0.8697

0.6147

0.7197

Shikimic acid metabolism

1.0000

1.0000

0.4901

0.9801

-1.2676

0.1745

0.3901

Histidine metabolism

0.5434

1.0000

1.0000

1.0000

1.8978

0.0080*

0.0520

Urea cycle

0.8567

1.0000

0.0507

0.2197

-1.3352

0.1524

0.3705

Proline metabolism

1.0000

1.0000

0.6001

1.0000

-1.1524

0.3041

0.4619

Polyamine metabolism

1.0000

1.0000

0.0308*

0.2000

-1.5785

0.0309*

0.1581

Tryptophan metabolism

0.7413

1.0000

0.9269

1.0000

-0.7141

0.8260

0.8764

Tyrosine metabolism

1.0000

1.0000

0.0752

0.2445

-1.3601

0.1176

0.3820

beta-alanine metabolism

0.2111

1.0000

0.8616

1.0000

0.9218

0.5531

0.7578

Taurine metabolism

1.0000

1.0000

0.3721

0.9675

-1.4114

0.1010

0.3535

Creatine metabolism

0.7874

1.0000

0.4705

0.9801

-0.8041

0.7093

0.7984

Purine metabolism

0.0285*

0.7411

0.9983

1.0000

1.6391

0.0220*

0.1290

Pyrimidine metabolism

0.9649

1.0000

0.9860

1.0000

0.7965

0.7355

0.7258

Ribonucleotide metabolism

0.3473

1.0000

1.0000

1.0000

1.1184

0.2800

0.6998

Deoxyribonucleotide

1.0000

1.0000

1.0000

1.0000

-0.6743

0.9776

0.8725

Conjugated bile acid

0.5361

1.0000

1.0000

1.0000

1.0384

0.3671

0.6834

Nicotinic acid metaboilsm

0.3473

1.0000

0.5357

0.9949

-0.8360

0.6536

0.8510

  1. *p < 0.05, **q < 0.05.
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BMC Bioinformatics

ISSN: 1471-2105

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