Skip to main content

Table 2 Results of MSEA in a comparative study of db / db mice treated with and without pioglitazone

From: Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis

 

ORA

Subramanian’s approach

 

Positive correlation with PC1

Negative correlation with PC1

Positive correlation with PC1

 

p-value

q-value

p-value

q-value

NES

p-value

q-value

Glycolysis

0.0090*

0.2250

0.7982

1.0000

1.6888

0.0198*

0.3485

Pentose phosphate pathway

1.0000

1.0000

1.0000

1.0000

1.3813

0.1378

0.9520

TCA cycle

1.0000

1.0000

1.0000

1.0000

-1.4237

0.0916

0.8261

Glutamic acid and glutamine metabolism

1.0000

1.0000

0.5471

1.0000

-1.2740

0.2062

0.4203

Alanine, aspartic acid and asparagine metabolism

0.5531

1.0000

1.0000

1.0000

0.7161

0.8049

1.0000

Lysine metabolism

1.0000

1.0000

1.0000

1.0000

-0.6892

0.8152

0.9603

Valine, leucine and isoleucine metabolism

0.3294

1.0000

1.0000

1.0000

0.8275

0.6150

0.9834

Glycine, serine and threonine metabolism

0.1405

0.7024

0.8617

1.0000

1.1241

0.2699

0.9823

Cysteine metabolism

0.7041

1.0000

0.2461

1.0000

-0.9727

0.4840

0.8845

Methionine metabolism

1.0000

1.0000

1.0000

1.0000

1.0388

0.4167

0.9189

Shikimic acid metabolism

0.3294

1.0000

1.0000

1.0000

1.1493

0.3098

1.0000

Histidine metabolism

1.0000

1.0000

1.0000

1.0000

0.7463

0.7770

1.0000

Urea cycle

1.0000

1.0000

1.0000

1.0000

0.6208

0.9293

0.9238

Proline metabolism

0.5051

1.0000

1.0000

1.0000

0.6493

0.8869

1.0000

Polyamine metabolism

0.1344

0.7024

0.2701

1.0000

1.0695

0.3818

0.9813

Tryptophan metabolism

0.1018

0.7024

1.0000

1.0000

1.2380

0.2247

1.0000

Tyrosine metabolism

0.4521

1.0000

1.0000

1.0000

0.9319

0.5367

0.8548

beta-alanine metabolism

0.3893

1.0000

0.6321

1.0000

0.6450

0.8899

0.9596

Taurine metabolism

0.0577

0.7024

0.4410

1.0000

0.9952

0.4654

0.8048

Creatine metabolism

1.0000

1.0000

0.7206

1.0000

-0.7887

0.7230

0.9414

Purine metabolism

1.0000

1.0000

0.2583

1.0000

-1.3788

0.0947

0.5203

Pyrimidine metabolism

1.0000

1.0000

0.9252

1.0000

-0.7940

0.7196

1.0000

Ribonucleotide metabolism

1.0000

1.0000

0.2461

1.0000

-1.3605

0.1215

0.3792

Conjugated bile acid

1.0000

1.0000

0.4687

1.0000

-0.5472

0.9689

0.9709

Nicotinic acid metaboilsm

0.3161

1.0000

0.5431

1.0000

0.9991

0.4427

0.8973

  1. *p < 0.05.
Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us