Table 2 Natural polymorphisms and unusual mutations of HIV-1 protease (p > 1%) without evidence of resistance to PIs
Mutation | p (%) | PV (%) | Region (PV) | Classification |
|---|---|---|---|---|
L5F | 1.67 | 1.67 | C (0.95) | UM |
Q7E | 1.52 | 1.89 | C (0.95) | UM |
T12P/S | 4.03/1.34 | 9.40 | V (8.04) | NP/NP |
K14R | 9.60 | 11.26 | V (9.97) | NP |
G17D/E | 1.99/1.32 | 3.31 | V (9.97) | UM/UM |
Q18H | 1.32 | 3.64 | V (9.97) | NP |
L19I/V/T | 4.64/1.32/ 1.32 | 7.95 | V (9.97) | NP/NP/NP |
D29V | 1.32 | 2.65 | SC(1.24) | UM |
N37S/T/C/H/I | 14.4/2.81/1.99/ 1.66/1.32 | 40.07 | HV(26.05) | NP/NP/NP/NP/UM |
P39S | 2.98 | 4.97 | SC(2.09) | NP |
K43R | 3.64 | 3.97 | SC(2.09) | NP |
Q61E | 2.65 | 3.97 | SC(4.47) | NP |
L63S/V/R/G/H | 1.99/149/1.99/1.32/1.32 | 84.77 | HV(22.02) | NP/NP/UM/UM/NP |
E65D | 2.0 | 2.67 | SC(2.0) | NP |
C67F | 2.0 | 3.33 | SC(2.0) | NP |
G68E | 4.30 | 5.96 | V(7.56) | UM |
H69Q | 1.99 | 7.62 | V(7.56) | NP |
K70R/T/I | 1.99/1.32/1.16 | 9.11 | V(7.56) | NP/UM/NP |
I72V/T/E/M | 11.26/6.95/2.32/1.32 | 24.50 | HV(27.48) | NP/NP/NP/UM |
P79L | 1.32 | 2.48 | SC(1.53) | UM |
T91V | 3.33 | 3.33 | SC(2.15) | UM |
Q92G/K | 2.03/2.03 | 4.05 | SC(2.15) | UM/UM |
I93F | 1.35 | 47.97 | HV(47.63) | UM |