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Table 3 Selection pressure for codons with unusual mutations and natural polymorphisms

From: Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis

Codon

Triplet

PV (%)

dN-dS

dN-dS (N)

P value*

Mutations

5

CTT

1.67

2.29

0.48

0.285

L5F

6

TGG

8.20

−5.97

−1.26

0.996

W6R

7

CAA

1.89

−15.57

−3.29

1.000

Q7E

29

GAT

2.65

20.20

4.26

0.003

D29V

63

CCC

84.77

2.01

0.42

0.196

L63A/R/S/V/G/H

70

AAA

9.11

−1.51

−0.32

0.964

K70I

79

CCT

2.48

4.44

0.94

0.190

P79L

91

ACT

3.33

5.01

1.12

0.086

T91V

92

CAG

4.05

−15.62

−3.46

0.990

Q92G;Q92K

93

ATT

47.97

28.64

6.34

1.000

I93F

  1. *P < 0.05 was considered statistically significant for positive pressure.
  2. PV, phenotypic variation; dN, number of non-synonymous substitutions per site (n/N); dS, number of synonymous substitutions per site (s/S); N, normalized; P, probability.
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BMC Bioinformatics

ISSN: 1471-2105

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