|  | Protease |  | aa/Chain-PIs |  | Protease |  |
---|---|---|---|---|---|---|---|
aa/Chain-PIs | Wild type | Resistant | Emergent | Wild type | Resistant | Emergent | |
PR-IDV | [2R5P] | [1K6C] | D29V | PR-LPV | [2Q5K] | [1RV7] | D29V |
29/A-N2 | 6.1 | 6.1 | 5.4 | 25/A-O4 | 5.4 | 6.8 | 9.1 |
29/B-O4 | 3.9 | 4.2 | 4.8 | 25/B-O4 | 5.5 | 7.8 | 9.9 |
30/A-N2 | 6.5 | 6.6 | 6.3 | 29/A-O1 | 5.8 | 10.8 | 6 |
30/B-O4 | 6.3 | 6.4 | 7 | 29/B-O3 | 6 | 10.3 | 5.3 |
82/A-O2 | 10.1 | 10.7 | 11.2 | 30/A-O1 | 3.7 | 9.8 | 7.1 |
82/B-N1 | 6.1 | 6.2 | 7.5 | 30/B-O3 | 6.7 | 10.1 | 5.3 |
84/A-O2 | 8.3 | 8.2 | 9.3 | 84/A-O4 | 8.2 | 10.1 | 10.4 |
84/B-N1 | 7.9 | 7.9 | 8.4 | 84/B-O3 | 7.6 | 8.1 | 8.2 |
PR-SQV | [3OXC] | [3CYW] | D29V | PR-RTV | [3NDX] | [1RL8] | D29V |
29/A-OD1 | 4.1 | 5.3 | 3.5 | 29/A-O76 | 4 | 3.8 | 4.9 |
29/B-N3 | 6.1 | 6 | 7.5 | 29/B-N5 | 5.6 | 4 | 5.1 |
30/A-OD1 | 3.8 | 4.2 | 3.8 | 30/A-O76 | 6.1 | 6.1 | 6.9 |
30/B-N3 | 6.5 | 6.4 | 7.5 | 30/B-S3 | 4 | 5.5 | 8.8 |
48/A-ND2 | 3.4 | 5.6 | 7.9 | 82/A-N11 | 9.4 | 9.5 | 9.6 |
48/B-N3 | 4 | 6.3 | 6.3 | 82/B-O7 | 10.5 | 10.3 | 11.6 |
PR-APV | [3NU3] | [3NU4] | D29V | PR-DRV | [IT3R] | [2HS1] | D29V |
29/A-O6 | 4.5 | 4.2 | 4 | 29/A-O26 | 3.9 | 4.1 | 10.4 |
29/B-N3 | 4.3 | 4.6 | 7.6 | 29/B-N1 | 4.6 | 4.4 | 7.3 |
30/A-O6 | 4.5 | 3.8 | 3.8 | 30/A-O26 | 3.8 | 3.8 | 12.3 |
30/B-N3 | 3.3 | 3.7 | 10.7 | 30/B-N1 | 3.8 | 3.7 | 9.5 |
32/A-O6 | 6.6 | 6.6 | 6.9 | 32/A-O26 | 7.2 | 7.5 | 13.9 |
32/B-N3 | 6.3 | 6.3 | 15 | 32/B-N1 | 6.1 | 7.6 | 13.3 |
PR-TPV | [2O4P] | [1DS4] | D29V | PR-ATV | [3EKY] | [3OXX] | D29V |
29/A-N28 | 6.1 | 6.2 | 9.6 | 29/A-OAI | 3.9 | 5.1 | 5.6 |
29/B-O1 | 9.1 | 9.4 | 8.4 | 29/B-OAJ | 3.9 | 4 | 8.3 |
30/A-N28 | 6.2 | 6 | 8.7 | 30/A-OAI | 6.1 | 6 | 8.7 |
30/B-O1 | 10 | 10.2 | 8.6 | 30/B-OAJ | 6 | 6 | 8.5 |
82/A-O8 | 10.7 | 10 | 10.2 | 50/A-O1 | 5.7 | 5.6 | 4.8 |
82/B-O7 | 10.3 | 9.9 | 7.7 | 50/B-O1 | 5.3 | 5.4 | 3.6 |
84/A-O8 | 8.3 | 8.1 | 8.5 | Â | Â | Â | Â |
84/B-O8 | 8.4 | 7.8 | 8.1 | Â | Â | Â | Â |
PR-NFV | [3EKX] | [2PYM] | D29V | Â | Â | Â | Â |
29/A-N12 | 5.9 | 6.3 | 5.8 | Â | Â | Â | Â |
29/B-O38 | 5 | 4.4 | 3.8 | Â | Â | Â | Â |
30/A-N12 | 6.4 | 6.7 | 6.3 | Â | Â | Â | Â |
30/B-O38 | 3.9 | 3.7 | 3.7 | Â | Â | Â | Â |