Table 1 Performance evaluation
| Â | Total number of responders and non-responders to the antibody | Performance in the full dataset | % accuracy within subtypes | Standard deviation across subtypes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antibody | # Responders | # Non-Reponders | Sensitivity (%) | Specificity (%) | Accuracy (%) | FN | FP | A (N = 21) | AE (N = 24) | AG (N = 19) | B (N = 55) | C (N = 32) | D (N = 55) | F1 (N = 24) | G (N = 41) | |
b12 | 61 | 221 | 98.2 | 77 | 93.6 | 4 | 14 | 90.5 | 91.7 | 89.5 | 92.7 | 96.9 | 94.5 | 100 | 92.7 | 3.47 |
pg16 | 177 | 105 | 74.3 | 93.2 | 86.2 | 27 | 12 | 90.5 | 83.3 | 94.7 | 89.1 | 75 | 89.1 | 83.3 | 82.9 | 6.10 |
pg9 | 178 | 104 | 64.4 | 94.4 | 83.3 | 37 | 10 | 85.7 | 91.7 | 94.7 | 87.3 | 71.9 | 81.8 | 83.3 | 75.6 | 7.65 |
pgt121 | 165 | 117 | 88 | 97.6 | 93.6 | 14 | 4 | 100 | 100 | 100 | 90.9 | 90.6 | 90.9 | 91.7 | 95.1 | 4.45 |
pgt122 | 150 | 132 | 88.6 | 92 | 90.4 | 15 | 12 | 95.2 | 100 | 89.5 | 90.9 | 90.6 | 85.5 | 83.3 | 92.7 | 5.26 |
pgt123 | 159 | 123 | 82.9 | 93.1 | 88.7 | 21 | 11 | 85.7 | 100 | 84.2 | 89.1 | 93.8 | 87.3 | 83.3 | 87.8 | 5.54 |
pgt125 | 130 | 152 | 90.8 | 82.3 | 86.9 | 14 | 23 | 76.2 | 87.5 | 89.5 | 90.9 | 87.5 | 92.7 | 91.7 | 78 | 6.25 |
pgt126 | 149 | 133 | 89.5 | 79.2 | 84 | 14 | 31 | 85.7 | 91.7 | 78.9 | 83.6 | 78.1 | 87.3 | 91.7 | 78 | 5.71 |
pgt127 | 118 | 164 | 87.2 | 82.2 | 85.1 | 21 | 21 | 90.5 | 87.5 | 94.7 | 80 | 78.1 | 90.9 | 87.5 | 82.9 | 5.74 |
pgt128 | 173 | 109 | 64.2 | 92.5 | 81.6 | 39 | 13 | 81 | 66.7 | 94.7 | 83.6 | 87.5 | 89.1 | 70.8 | 70.7 | 10.11 |
pgt130 | 146 | 136 | 82.4 | 87.7 | 85.1 | 24 | 18 | 81 | 87.5 | 78.9 | 85.5 | 84.4 | 87.3 | 87.5 | 82.9 | 3.23 |
pgt131 | 101 | 181 | 90.6 | 76.2 | 85.5 | 17 | 24 | 85.7 | 79.2 | 78.9 | 89.1 | 96.9 | 80 | 87.5 | 80.5 | 6.33 |
pgt135 | 66 | 216 | 98.1 | 77.3 | 93.3 | 4 | 15 | 95.2 | 100 | 89.5 | 98.2 | 87.5 | 94.5 | 87.5 | 92.7 | 4.72 |
pgt136 | 31 | 251 | 99.2 | 77.4 | 96.8 | 2 | 7 | 100 | 100 | 94.7 | 98.2 | 90.6 | 98.2 | 100 | 92.7 | 3.67 |
pgt137 | 31 | 251 | 100 | 61.3 | 95.7 | 0 | 12 | 100 | 100 | 94.7 | 94.5 | 93.8 | 96.4 | 95.8 | 95.1 | 2.42 |
pgt141 | 121 | 161 | 92.5 | 90.1 | 91.5 | 12 | 12 | 66.7 | 95.8 | 84.2 | 94.5 | 93.8 | 98.2 | 83.3 | 92.7 | 10.35 |
pgt142 | 139 | 143 | 90.9 | 89.9 | 90.4 | 13 | 14 | 100 | 83.3 | 89.5 | 87.3 | 90.6 | 90.9 | 91.7 | 95.1 | 4.98 |
pgt143 | 140 | 142 | 89.4 | 92.9 | 91.1 | 15 | 10 | 95.2 | 79.2 | 94.7 | 92.7 | 84.4 | 87.3 | 95.8 | 100 | 6.91 |
pgt144 | 73 | 209 | 96.7 | 86.3 | 94 | 7 | 10 | 100 | 91.7 | 94.7 | 92.7 | 93.8 | 96.4 | 87.5 | 95.1 | 3.64 |
pgt145 | 132 | 150 | 89.3 | 91.7 | 90.4 | 16 | 11 | 85.7 | 87.5 | 84.2 | 90.9 | 93.8 | 90.9 | 91.7 | 95.1 | 3.84 |
pgv04 | 216 | 66 | 72.7 | 95.4 | 90.1 | 18 | 10 | 85.7 | 95.8 | 84.2 | 94.5 | 90.6 | 89.1 | 95.8 | 82.9 | 5.22 |