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Table 2 A comparison of the 15 proteins that were found to contain significant clustering via GraphPAC , iPAC or NMC

From: A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations

  GraphPAC iPAC NMC
Protein p-value p* p-value p* p-value p*
KRAS 4.21 E-233 4.33 E-229 6.17 E-185 6.35 E-181 4.39 E-233 4.52 E-229
TP53 4.05 E-152 4.48 E-147 5.23 E-128 6.11 E-123 4.37 E-086 5.30 E-081
BRAF 3.84 E-130 1.04 E-126 3.73 E-130 1.01 E-126 3.84 E-130 1.04 E-126
PIK3CA 8.20 E-084 3.58 E-080 8.20 E-084 3.58 E-080 8.20 E-084 3.58 E-080
NRAS 8.26 E-029 9.91 E-027 5.38 E-026 6.46 E-024 8.26 E-029 9.91 E-027
HRAS 1.54 E-014 6.94 E-013 1.23 E-010 5.54 E-009 5.61 E-010 8.42 E-009
AKT1 2.47 E-005 2.47 E-004 1.18 E-005 7.08 E-005 2.47 E-005 7.41 E-005
IDE 1.56 E-003 4.67 E-003 2.20 E-005 6.60 E-005 1.56 E-003 4.67 E-003
EGFR 9.04 E-004 9.04 E-003 1.35 E-004 1.35 E-003 - -
DPP4 3.17 E-003 3.63 E-002 - - - -
MAP2K4 1.21E-003 1.21E-002 - - - -
NRP1 1.58E-002 1.58E-002 - - - -
PCSK9 5.61 E-003 1.68E-002 - - - -
HAO1 - - 7.95 E-003 2.39 E-002 - -
EIF2AK2 - - 2.45 E-003 7.36 E-003 - -
  1. If a specific method did not find a particular protein to contain significant clustering, a "-" is shown. The p* calculation is described in Section ‘Multiple comparison adjustment for structures’. The smallest p-value from all of the insertion methods was selected.