A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations

BMC Bioinformatics

Table 4 A comparison of GraphPAC and NMC identified clusters for the BRAF structure

(a) Clusters found by GraphPAC
			p-value
Start	End	# Muts.	GraphPAC	NMC
600	600	60	2.12E-129	2.12E-129
597	600	62	1.49E-104	1.49E-104
600	601	62	1.49E-104	9.22E-117
596	600	64	7.16E-102	7.16E-102
596	601	66	3.37E-91	1.16E-100
597	601	64	8.07E-91	7.16E-102
601	671	3	5.85E-38	-
600	671	63	8.30E-37	7.08E-26
469	601	72	2.59E-22	5.92E-17
581	601	68	1.23E-21	1.33E-65
581	600	66	2.94E-20	3.13E-63
469	600	70	3.98E-20	4.91E-15
466	601	74	2.15E-17	9.69E-19
466	600	72	7.01E-16	1.60E-16
464	601	75	1.15E-15	1.12E-19
464	600	73	2.33E-14	2.97E-17
(b) Clusters found by *NMC* and dropped by *GraphPAC*
Start	End	# Muts.		*NMC* Pvalue
596	671	67		4.12E-29
597	671	65		4.79E-27
581	671	69		3.33E-26
464	671	76		5.92E-09
466	671	75		3.32E-08
469	671	73		8.11E-07

A "-" for the NMC value signifies that cluster was not identified under the linear algorithm.

ISSN: 1471-2105