Receiver operating characteristic curves for low and high inter-study variability. Receiver Operating Characteristic (ROC) curves, averaged over 300 datasets. Each plot represents the results of a particular setting, with columns corresponding (from left to right) to simulations including 2 studies, 3 studies, and 5 studies, and rows corresponding (from top to bottom) to simulations with inter-study variability set to σ=0.15 and σ=0.50 (small to large inter-study variability). Within each plot: Fisher (red lines), global analysis with no fixed study effect (DESeq (no study), blue lines), and global analysis with a fixed study effect (DESeq (study), orange lines). The dotted black line represents the diagonal.