QCMF-significant residue positions are in contact with catalytic residues in human EGFR protein (PDB-Entry 2J6M). Red spheres denote positions of the catalytic residues. Yellow spheres show the localization of significant adjacent residue positions found by QCMF which are in contact with these catalytic residues. Moreover, the QCMF-significant sites A839 and R841 are also catalytic residues by themselves. Green spheres show the structural localization of nsSNP positions found by QCMF as significant in the EGFR protein. The circles indicate clusters of catalytic residue sites and their significant adjacent sites.