QCMF-significant residue positions are in contact with gefitinib binding sites in human EGFR protein (PDB-Entry 2J6M). Red spheres show the structural localization of the gefitinib binding sites in the wild type kinase. Yellow spheres show QCMF-significant adjacent residue positions which are in contact with these binding sites. Moreover, the QCMF-significant site T854 is also a binding site by itself and interacts with gefitinib binding site D855. The circles indicate clusters of gefitinib binding sites and their significant adjacent sites.