Table 2 QCMF-significant essential sites in the human GCK protein, which are nearby either nsSNPs or strictly conserved sites

M37

36^s,39^s,40^s

[38, 39, 43, 51]

S76

147^c

L79

78^c,80^c,150^c

-

T82

81^c

-

N83

81^c,108^s,110^s

[43, 51]

V86

85^c,106^s

[38]

S127

130^s

[40]

F148

147^c,150^c,s

[38, 39, 43, 51]

F152

150^c,s, 151^c

[39, 43, 51]

P153

154^s

[39]

H156

154^s

[39]

A176

119^s,175^s

[43]

G178

164^c

N180

162^s,182^s

[38, 39, 43],

L185

182^s,188^s

[39, 43, 51]

A201

147^c,453^c

M202

147^c,203^s

[43]

A232

223^s,231^c

[39, 40, 51]

C233

223^s,234^c,235^c

[39, 40, 51]

V253

234^c,254^c

F260

257^s,258^c,259^s,261^s

[39, 43]

L271

274^c

V277

274^c,278^c,279^s

[43]

S281

278^c,279^s

[43]

Y297

291^c,295^c,299^c, 300^s

[43]

M298

295^c,299^c,300^s

[43]

T332

295^c,299^c

V374

377^c

A378

377^c,382^s

[43]

A379

377^c,382^s

[43]

S383

382^s,385^s

[43]

A384

382^s,385^s

[43]

A387

385^s

[43]

S388

385^s,392^s

[38, 43]

V412

226^s,227^c,410^c,414^s,416^s

[40, 43]

F419

416^s

[40]

E443

444^c,445^c,447^s

[39]

G446

444^c,445^c,447^s,448^c,449^c

[39]