BMC Bioinformatics

Table 2 QCMF-significant essential sites in the human GCK protein, which are nearby either nsSNPs or strictly conserved sites

From: Quantum coupled mutation finder: predicting functionally or structurally important sites in proteins using quantum Jensen-Shannon divergence and CUDA programming

QCMF-significant	Nearby nsSNPs or strictly	Reference
essential sites	conserved sites
M37	36^s,39^s,40^s	[38, 39, 43, 51]
S76	147^c
L79	78^c,80^c,150^c	-
T82	81^c	-
N83	81^c,108^s,110^s	[43, 51]
V86	85^c,106^s	[38]
S127	130^s	[40]
F148	147^c,150^c,s	[38, 39, 43, 51]
F152	150^c,s, 151^c	[39, 43, 51]
P153	154^s	[39]
H156	154^s	[39]
A176	119^s,175^s	[43]
G178	164^c
N180	162^s,182^s	[38, 39, 43],
L185	182^s,188^s	[39, 43, 51]
A201	147^c,453^c
M202	147^c,203^s	[43]
A232	223^s,231^c	[39, 40, 51]
C233	223^s,234^c,235^c	[39, 40, 51]
V253	234^c,254^c
F260	257^s,258^c,259^s,261^s	[39, 43]
L271	274^c
V277	274^c,278^c,279^s	[43]
S281	278^c,279^s	[43]
Y297	291^c,295^c,299^c, 300^s	[43]
M298	295^c,299^c,300^s	[43]
T332	295^c,299^c
V374	377^c
A378	377^c,382^s	[43]
A379	377^c,382^s	[43]
S383	382^s,385^s	[43]
A384	382^s,385^s	[43]
A387	385^s	[43]
S388	385^s,392^s	[38, 43]
V412	226^s,227^c,410^c,414^s,416^s	[40, 43]
F419	416^s	[40]
E443	444^c,445^c,447^s	[39]
G446	444^c,445^c,447^s,448^c,449^c	[39]

^s: non-synonymous snp site, ^c: strictly conserved site.

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