Table 2 Ranking positions and assigned scores for top prioritized genes for each case study

Gene

Rank

Score

Gene

Rank

Score

Gene

Rank

Score

Gene

Rank

Score

APP*

1

0.6639

PSEN1

4

0.1946

CST3

7

0.1511

SNCA

10

0.1276

PSEN2*

2

0.5462

TREM2

5

0.1700

ITM2B

8

0.1468

APOE

11

0.1141

MAPT

3

0.2531

HD/HTT

6

0.1585

TYROBP

9

0.1296

NCSTN

12

0.1114

Gene

Rank

Score

Gene

Rank

Score

Gene

Rank

Score

Gene

Rank

Score

IRS1*

1

0.4744

INSR*

5

0.2950

LEPRE1

9

0.0976

ABCC8

37

0.0456

PPP1R3A*

2

0.4660

TCF1*

6

0.2168

LEPREL4

10

0.0976

SLC2A4*

3

0.4194

PLN

7

0.1164

NEUROD1

14

0.0905

IPF1*

4

0.3308

HADHSC

8

0.0976

KCNJ11

30

0.0595

Breast Cancer (MIM:114480)

Gene

Rank

Score

Gene

Rank

Score

Gene

Rank

Score

Gene

Rank

Score

BRCA1*

1

0.5019

PIK3CA*

5

0.3199

ELAC2

9

0.1038

ATM

13

0.0934

RAD51*

2

0.4919

MSH2

6

0.1636

RAD51AP1

10

0.1031

CHEK2

29

0.0551

BRCA2*

3

0.4813

RB1

7

0.1607

RAD54L

11

0.1031

NBN/NBS1*

4

0.3547

TP53

8

0.1307

FANCD2

12

0.1017