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Table 2 Ranking positions and assigned scores for top prioritized genes for each case study

From: ProphNet: A generic prioritization method through propagation of information

Alzheimer Disease (MIM:104300)
Gene Rank Score Gene Rank Score Gene Rank Score Gene Rank Score
APP* 1 0.6639 PSEN1 4 0.1946 CST3 7 0.1511 SNCA 10 0.1276
PSEN2* 2 0.5462 TREM2 5 0.1700 ITM2B 8 0.1468 APOE 11 0.1141
MAPT 3 0.2531 HD/HTT 6 0.1585 TYROBP 9 0.1296 NCSTN 12 0.1114
Diabetes Mellitus Type 2 (MIM:125853)
Gene Rank Score Gene Rank Score Gene Rank Score Gene Rank Score
IRS1* 1 0.4744 INSR* 5 0.2950 LEPRE1 9 0.0976 ABCC8 37 0.0456
PPP1R3A* 2 0.4660 TCF1* 6 0.2168 LEPREL4 10 0.0976    
SLC2A4* 3 0.4194 PLN 7 0.1164 NEUROD1 14 0.0905    
IPF1* 4 0.3308 HADHSC 8 0.0976 KCNJ11 30 0.0595    
Breast Cancer (MIM:114480)
Gene Rank Score Gene Rank Score Gene Rank Score Gene Rank Score
BRCA1* 1 0.5019 PIK3CA* 5 0.3199 ELAC2 9 0.1038 ATM 13 0.0934
RAD51* 2 0.4919 MSH2 6 0.1636 RAD51AP1 10 0.1031 CHEK2 29 0.0551
BRCA2* 3 0.4813 RB1 7 0.1607 RAD54L 11 0.1031    
NBN/NBS1* 4 0.3547 TP53 8 0.1307 FANCD2 12 0.1017    
  1. Gene symbol, rank position and assigned score for genes in the top of the ranking for each case study. Entries marked with asterisks were directly connected by an arc to the disease of interest in the data network.