Figure 1

Estrogen receptor ligand binding domain. 1a The ER LBD comprising twelve α-helices and a beta sheet/hairpin: The twelve α-helices (H1-12) are colored differently for clarity; 1b conformation of an active ER and 1c conformation of an inactive ER. The major difference between 1b and 1c lies in the H12 conformation, highlighted in red.