All-atom analysis of the ERα crystal structures. The graph shows the all-atom RMSD for five pairs of ERα complexes found to be interesting in the study. Note: "agonist" with parentheses represents structure which was bound to an antagonist according to the literature, but demonstrated an agonist conformation, and vice versa for the "antagonist" structure. Letters G and N in front of the PDB IDs denote the types of ligand bound to the structures, as reported in the literature. Major differences were found between the antagonist's and antagonist's conformations whereby these differences were found to lie in the region between residues 338-340 (loop linking helix 2 and helix 3) and 532-548 (end of helix 11 to end of helix 12). See Figure 7 for diagrams showing these differences.