| |
Agonist
|
Antagonist
|
|---|
| |
SDM
|
CDA
|
SDM
|
CDA
|
|---|
|
1%
|
20.5
|
23.6
|
12.7
|
12.7
|
|
2%
|
17.9
|
19.3
|
21.6
|
21.6
|
|
3%
|
14.8
|
14.8
|
17.8
|
17.8
|
|
4%
|
13.9
|
12.7
|
15.3
|
15.3
|
|
5%
|
12.1
|
10.3
|
12.2
|
12.2
|
|
20%
|
3.8
|
3.1
|
3.2
|
3.2
|
|
Max
|
39.4
|
23.6
|
21.8
|
21.6
|
- Comparisons of the calculated EFs at different % of database screened and EFmax for the SDMs and CDA. For agonist screening, CDA performs better at the early stage (1-3%) compared to SDM. For antagonist screening, comparable results are obtained. The EFmax for the SDMs are better than the CDA, however, these peaks occur at a later stage of screening.
