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Table 1 Tabular view of variant dynamics and clonal evolution.

From: Revealing the inherent heterogeneity of human malignancies by variant consensus strategies coupled with cancer clonal analysis

  

Presentation

Relapse #1

Relapse #2

Gene

Symbol

Func.

Class

VAF

%

CN

DP

VAF

%

CN

DP

VAF

%

CN

DP

ARHGAP26

VUS

26

3

70

25

3

59

26

2

46

ARID1A

TSG

50

2

52

44

2

57

28

2

43

ATM

TSG

49

3

49

54

3

46

NP

NP

NP

CD36

VUS

NP

NP

NP

NP

NP

NP

23

2

73

ERBB4

VUS

34

2

76

37

2

79

32

2

50

ESR1

VUS

NP

NP

NP

15

2

107

NP

NP

NP

FOXO3

VUS

NP

NP

NP

21

2

68

NP

NP

NP

JAK3

OG

NP

NP

NP

12

3

66

NP

NP

NP

KRAS

OG

NP

NP

NP

NP

NP

NP

35

2

40

NRAS

OG

44

2

87

19

1

91

NP

NP

NP

NTRK3

VUS

NP

NP

NP

18

3

119

NP

NP

NP

PARP1

DR

45

2

65

39

2

66

32

2

41

PMS2P3

DR

NP

NP

NP

11

3

76

NP

NP

NP

POLE

DR

NP

NP

NP

NP

NP

NP

29

2

48

POLK

DR

NP

NP

NP

19

2

58

NP

NP

NP

  1. A tabular form of the clonal dynamics as shown in figure 2 illustrates changes in VAF, copy number, and depth across the Presentation, Relapse #1 and Relapse #2 samples. Abbreviations: CN (Copy Number), DP (Depth), DR (DNA Repair), NP (Not Present), OG (Oncogene), VAF (Variant Allele Frequency), VUS (Variant of Uncertain Significance) and TSG (Tumor Suppressor Gene).