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Table 1 Tabular view of variant dynamics and clonal evolution.

From: Revealing the inherent heterogeneity of human malignancies by variant consensus strategies coupled with cancer clonal analysis

   Presentation Relapse #1 Relapse #2
Gene Symbol Func. Class VAF % CN DP VAF % CN DP VAF % CN DP
ARHGAP26 VUS 26 3 70 25 3 59 26 2 46
ARID1A TSG 50 2 52 44 2 57 28 2 43
ATM TSG 49 3 49 54 3 46 NP NP NP
CD36 VUS NP NP NP NP NP NP 23 2 73
ERBB4 VUS 34 2 76 37 2 79 32 2 50
ESR1 VUS NP NP NP 15 2 107 NP NP NP
FOXO3 VUS NP NP NP 21 2 68 NP NP NP
JAK3 OG NP NP NP 12 3 66 NP NP NP
KRAS OG NP NP NP NP NP NP 35 2 40
NRAS OG 44 2 87 19 1 91 NP NP NP
NTRK3 VUS NP NP NP 18 3 119 NP NP NP
PARP1 DR 45 2 65 39 2 66 32 2 41
PMS2P3 DR NP NP NP 11 3 76 NP NP NP
POLE DR NP NP NP NP NP NP 29 2 48
POLK DR NP NP NP 19 2 58 NP NP NP
  1. A tabular form of the clonal dynamics as shown in figure 2 illustrates changes in VAF, copy number, and depth across the Presentation, Relapse #1 and Relapse #2 samples. Abbreviations: CN (Copy Number), DP (Depth), DR (DNA Repair), NP (Not Present), OG (Oncogene), VAF (Variant Allele Frequency), VUS (Variant of Uncertain Significance) and TSG (Tumor Suppressor Gene).