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Table 2 Key residues covered by APC and their roles in the Co-occurrence Cluster 1 of ubiquitin

From: Discovering co-occurring patterns and their biological significance in protein families

APC Residue(s) Role(s) Literature
1 K6, K11 Lys(K)6 and Lys(K)11 are used for forming ubiquitin chain(s) in ubiquitination. [23]
  L8 Leu(8) facilitates the interaction between ubiquitin and E1 enzymes. [24, 27]
2 K11, K27 Lys(K)11 and Lys(K)27 are used for forming ubiquitin chain(s) in ubiquitination. [23]
  L8 Leu(8) facilitates the interaction between ubiquitin and E1 enzymes. [24, 27]
3 K63 Lys(K)63 is used for forming ubiquitin chain(s) in ubiquitination.  
  H68, V70 His(H)68 and Val(V)70 facilitate the binding between ubiquitin and ubiquitin-binding protiens. [24, 27]
  R72 Arg(R)72 facilitates the interaction between ubiquitin and E1 enzymes. [25]
  G75,G76 Gly(G)75 and Gly(G)76 are are used for forming ubiquitin chain(s) in ubiquitination. [23]
4 R42 Arg(R)42 facilitates the interaction between ubiquitin and E1 enzymes. [25]
  I44 Ile(I) 44 is the binding site between ubiquitin and the ubiquitin-binding proteins. [24, 27]
  K48 Lys(K)48 is used for forming ubiquitin chain(s) in ubiquitination. It also facilitates the binding between ubiquitin and ubiquitin-binding proteins. [23, 24, 27]
5 K27,K29,K33 Lys(K)27, Lys(K)29 and Lys(K)33 are used for forming ubiquitin chain(s) in ubiquitination. [23]
  R42 Arg(R)42 facilitates the interaction between ubiquitin and E1 enzymes. [25]