Table 2 Key residues covered by APC and their roles in the Co-occurrence Cluster 1 of ubiquitin
From: Discovering co-occurring patterns and their biological significance in protein families
APC | Residue(s) | Role(s) | Literature |
|---|---|---|---|
1 | K6, K11 | Lys(K)6 and Lys(K)11 are used for forming ubiquitin chain(s) in ubiquitination. | [23] |
| Â | L8 | Leu(8) facilitates the interaction between ubiquitin and E1 enzymes. | |
2 | K11, K27 | Lys(K)11 and Lys(K)27 are used for forming ubiquitin chain(s) in ubiquitination. | [23] |
| Â | L8 | Leu(8) facilitates the interaction between ubiquitin and E1 enzymes. | |
3 | K63 | Lys(K)63 is used for forming ubiquitin chain(s) in ubiquitination. | Â |
| Â | H68, V70 | His(H)68 and Val(V)70 facilitate the binding between ubiquitin and ubiquitin-binding protiens. | |
| Â | R72 | Arg(R)72 facilitates the interaction between ubiquitin and E1 enzymes. | [25] |
| Â | G75,G76 | Gly(G)75 and Gly(G)76 are are used for forming ubiquitin chain(s) in ubiquitination. | [23] |
4 | R42 | Arg(R)42 facilitates the interaction between ubiquitin and E1 enzymes. | [25] |
| Â | I44 | Ile(I) 44 is the binding site between ubiquitin and the ubiquitin-binding proteins. | |
| Â | K48 | Lys(K)48 is used for forming ubiquitin chain(s) in ubiquitination. It also facilitates the binding between ubiquitin and ubiquitin-binding proteins. | |
5 | K27,K29,K33 | Lys(K)27, Lys(K)29 and Lys(K)33 are used for forming ubiquitin chain(s) in ubiquitination. | [23] |
| Â | R42 | Arg(R)42 facilitates the interaction between ubiquitin and E1 enzymes. | [25] |