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Table 4 Key residues covered by APCs and their roles in co-occurrence cluster 2 of cytochrome c

From: Discovering co-occurring patterns and their biological significance in protein families

APC Residue(s) Role(s) Literature
4 Cys(C)14 Cys(C) 14 enhances axial ligand strength between His18 and the heme. [32, 33]
  Cys(C)17 Cys(C) 17 enhances axial ligand strength between His18 and the heme. [32, 33]
  His(H)18 His(H)18 forms an axial ligand with the heme from the proximal front. [34, 35]
5 Tyr(Y)67 Tyr(Y)67, its hydroxyl group, forms a H-bond with side chains of Met80 for structural stabilization. [36, 28]
  Pro(P)71 Pro(P)71 helps coordinate the axial ligand between Met80 and the heme. [37]
  Pro(P)76 Pro(P)76 helps coordinate the axial ligand between Met80 and the heme. [38]
  Met(M)80 Met(M)80 forms an axial ligand with the heme from the distal side. [34, 35]
  Phe(F)82 Phe(F)82 helps stabilize the native heme environment. [39]
6 Gly(G)41 Gly(G)41 helps stabilize the axial ligand between Met80 and the heme. [40]
7 Asn(N)52 Asn(N)52 maintains a hydrogen bond with the heme to stabilize the environment. [41, 42]
8 Leu(L)94 One of Leu(L)94 or Tyr(Y)97 is required to provide a hydrophobic environment for the function of cyt-c. [43]
  Tyr(Y)97 One of Leu(L)94 or Tyr(Y)97 is required to provide a hydrophobic environment for the function of cyt-c. [43]