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Figure 1 | BMC Bioinformatics

Figure 1

From: BIMMER: a novel algorithm for detecting differential DNA methylation regions from MBDCap-seq data

Figure 1

The proposed bi-layer HMM for differential methyulation analysis. The first layer HMMs model the methylation statuses in the normal and disease samples in the bins, where X c 's and m c 's represent the reads counts and the methylations status in the normal samples, respectively, and X n 's and m n 's those in the cancer samples. The second layer HMM models the relationship between the differntial methylation status, dm, and the methylations statuses of m n and m c .

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