Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease

Johnson, Piers; Vandewater, Luke; Wilson, William; Maruff, Paul; Savage, Greg; Graham, Petra; Macaulay, Lance S; Ellis, Kathryn A; Szoeke, Cassandra; Martins, Ralph N; Rowe, Christopher C; Masters, Colin L; Ames, David; Zhang, Ping

doi:10.1186/1471-2105-15-S16-S11

BMC Bioinformatics

Table 9 Mean values of each variable for the different clinical groups.

From: Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease

Variable	HC	MCI	AD	HC convert to MCI/AD			MCI convert to AD
				Non_Converters	Converters	Pvalue (t,chisq)	Non_converters	Converters	Pvalue
v1	28.84	26.20	19.10	28.96	28.23	<0.001	27.37	25.79	0.002
v2	12.90	6.51	3.24	13.24	9.84	<0.001	7.53	5.91	0.034
v3	11.38	3.79	1.02	11.80	7.10	<0.001	5.03	3.04	0.012
v4	0.92	0.31	0.09	0.07	0.27	<0.001	0.60	0.70	0.498
v5	60.55	38.30	26.56	61.35	51.23	<0.001	41.07	35.40	0.001
v6	0.87	-1.37	-2.21	0.95	-0.03	<0.001	-1.18	-1.81	0.001
v7	0.79	-1.62	-2.53	0.89	-0.05	<0.001	-1.38	-2.02	0.002
v8	0.09	-1.16	-1.90	0.12	0.21	0.269	-0.98	-1.22	0.247
v9	-0.21	1.16	2.14	-0.26	0.58	<0.001	0.72	1.65	0.001
v10	0.46	-1.21	-2.06	0.52	-0.10	0.000	-0.70	-1.52	<0.001
v11	-0.54	-1.49	-3.23	-0.49	-0.84	0.052	-1.42	-1.61	0.364
v12	-1.01	-0.78	-0.49	-1.00	-1.00	0.481	-0.76	-0.76	0.488
v13	0.48	-0.82	-1.92	0.50	0.06	0.019	-0.52	-1.13	0.015
v14	0.53	-1.02	-2.15	0.56	0.06	0.016	-0.58	-1.39	0.010
v15	0.31	-1.15	-2.91	0.33	0.34	0.490	-0.36	-1.88	<0.001
v16	12.04	10.04	7.32	12.17	11.06	0.066	9.23	9.57	0.338
v17	12.38	9.03	5.31	12.50	11.87	0.120	9.23	8.83	0.305
v18	12.13	8.25	4.46	12.33	9.71	0.000	8.87	7.57	0.054
v19	12.15	8.60	4.89	12.34	9.87	0.001	9.33	7.59	0.015
v20	0.74	0.18	-1.12	0.78	0.72	0.329	0.44	0.03	0.047
v21	0.72	0.27	-0.82	0.76	0.66	0.260	0.50	0.27	0.206
v22	12.00	11.11	9.10	12.11	12.06	0.465	10.73	11.09	0.285
V23	11.68	9.85	6.53	11.76	10.65	0.019	10.13	9.33	0.131
v24	108.33	105.92	100.84	108.46	107.32	0.227	103.47	107.53	0.072
v25	111.62	108.91	104.22	111.82	110.32	0.132	106.60	110.32	0.072
v26	-0.05	0.48	2.10	-0.03	0.08	0.280	0.63	0.38	0.237
v27	0.02	0.08	0.28	0.03	0.06	0.277	0.26	0.04	0.145
v28	0.06	0.94	4.57	0.02	0.64	0.035	0.90	1.09	0.362
v29	0.08	0.17	0.64	0.07	0.23	0.147	0.19	0.29	0.254
v30	-0.34	0.35	1.83	-0.36	0.13	0.004	0.31	0.39	0.424
v31	0.73	1.55	3.08	0.67	1.06	0.105	1.00	1.76	0.074
v32	-0.32	0.05	0.57	-0.34	-0.02	0.046	-0.10	0.02	0.299
V33	9.75	9.31	7.22	9.79	9.90	0.083	9.60	9.33	0.117
V34	43.12	40.48	36.32	43.31	41.84	0.111	38.40	41.79	0.076
v35	0.04	1.21	5.74	0.03	0.15	0.025	0.73	1.37	<0.001
v36	2.62	3.71	4.06	2.56	3.07	0.116	3.90	3.24	0.148
v37	4.33	4.94	4.98	4.28	4.20	0.428	4.97	4.52	0.238

Columns HC, MCI and AD are the mean values of each variable (cognitive test). The other columns are the means values for the groups of converters and non-converters from HC or from MCI with the t-test (chi-square test for variable 4, a dichotomous variable with values Pass and Fail) for the comparison between the 2 groups.

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ISSN: 1471-2105

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