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Table 1 Values of various physico-chemical descriptors.

From: Computational identification of novel natural inhibitors of glucagon receptor for checking type II diabetes mellitus

Descriptors CAA PIB MK-0893 LY2409021 Recommended range
#star 0 0 4 0 0-5
Molecular weight 373.405 498.968 588.489 294.35 <500
Hydrogen bond donors 1.25 1 4.25 1 <5
Hydrogen bond acceptors 7 5 5.25 5.5 <10
logP 2.618 5.485 8.18 -1.062 <5
SASA 707.226 652.412 900.01 594.833 300-1000
Oral absorption 64.462 100 85.123 28.784 >80% high
<25% poor
CNS activity 0 -2 -2 -2 -2 inactive
2 active
Blood brain barrier partition coefficient -2.063 -0.317 -1.179 -1.8 -3.0-1.2
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