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Table 1 Binding affinities of the 31 globulin binding steroids [31].

From: Combining spatial and chemical information for clustering pharmacophores

Molecule

ID

CBG (pKa)

Deoxycortisol

11

-7.881

Corticosterone

6

-7.881

Cortisol

7

-7.881

Hydroxyprogesterone

20

-7.740

2a-methylcortisol

30

-7.688

Deoxycorticosterone

10

-7.653

Cortisolacetate

23

-7.553

Prednisolone

22

-7.512

Progesterone

19

-7.380

Epicorticosterone

25

-7.200

17a-methylprogesterone

28

-7.120

Cortisone

8

-6.892

19-Norprogesterone

29

-6.817

4-Pregnene-3,11,20-trione

24

-6.779

Testosterone

21

-6.724

Aldosterone

1

-6.279

16a,17a-Dihydroxyprogesterone

27

-6.247

19-Nortestosterone

26

-6.144

Dihydrotestosterone

12

-5.919

2a-methyl-9a-fluorocortisol

31

-5.797

4-Androstenedion

4

-5.763

Androsterone

5

-5.613

Pregnenolone

17

-5.225

Etiocholanolone

16

-5.225

Androstanediol

2

-5.000

5-Androstenediol

3

-5.000

Dehydroepiandrosterone

9

-5.000

Estradiol

13

-5.000

Estriol

14

-5.000

Estrone

15

-5.000

Hydroxypregenolone

18

-5.000