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Table 1 Binding affinities of the 31 globulin binding steroids [31].

From: Combining spatial and chemical information for clustering pharmacophores

Molecule ID CBG (pKa)
Deoxycortisol 11 -7.881
Corticosterone 6 -7.881
Cortisol 7 -7.881
Hydroxyprogesterone 20 -7.740
2a-methylcortisol 30 -7.688
Deoxycorticosterone 10 -7.653
Cortisolacetate 23 -7.553
Prednisolone 22 -7.512
Progesterone 19 -7.380
Epicorticosterone 25 -7.200
17a-methylprogesterone 28 -7.120
Cortisone 8 -6.892
19-Norprogesterone 29 -6.817
4-Pregnene-3,11,20-trione 24 -6.779
Testosterone 21 -6.724
Aldosterone 1 -6.279
16a,17a-Dihydroxyprogesterone 27 -6.247
19-Nortestosterone 26 -6.144
Dihydrotestosterone 12 -5.919
2a-methyl-9a-fluorocortisol 31 -5.797
4-Androstenedion 4 -5.763
Androsterone 5 -5.613
Pregnenolone 17 -5.225
Etiocholanolone 16 -5.225
Androstanediol 2 -5.000
5-Androstenediol 3 -5.000
Dehydroepiandrosterone 9 -5.000
Estradiol 13 -5.000
Estriol 14 -5.000
Estrone 15 -5.000
Hydroxypregenolone 18 -5.000